Key result
Etomidate resulted in significantly lower plasma cortisol concentrations at 180 minutes post-induction compared to dexmedetomidine or control in children undergoing congenital heart disease surgery.
Why the study?
Does dexmedetomidine prevent adrenal suppression compared to etomidate in pediatric patients undergoing congenital heart disease corrective surgery?
Does dexmedetomidine prevent adrenal suppression compared to etomidate in pediatric patients undergoing congenital heart disease corrective surgery?
Etomidate induces more severe and prolonged adrenal suppression compared to dexmedetomidine in children undergoing congenital heart disease surgery.
Etomidate-associated cortisol suppression warrants caution in pediatric CHD surgery; leaves open dexmedetomidine's protective role pending RCTs.
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Jinfen Liu (2015) studied Congenital heart disease (n=99). Etomidate vs. Dexmedetomidine (0.5 µg/kg bolus + 0.5 µg/kg/h) or routine anesthetics was evaluated on Plasma cortisol concentration. Etomidate resulted in significantly lower plasma cortisol concentrations at 180 minutes post-induction compared to dexmedetomidine or control in children undergoing congenital heart disease surgery.
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