The level of IL-4, -8, -10 in cord blood of full-term newborns in dependence of Vitamin D3 supplementation during pregnancy

The aim – to study the interrelation of cord blood level of vitamin D3 and interleukins (IL) -4, -8, -10 with the dose of vitamin D3 supplementation during pregnancy. The cord blood level of IL-4, -8, -10 and vitamin D3 have been studied in 119 newborns. Data have been analysis separately in dependence on taking of vitamin D3 –containing drags during pregnancy (group I - did not receive vitamin D3, group II-l received <400-500 UE/ml irregularly, II-2 and II-3 had 400-500 UE/ml and 800-120 UE/ml daily during pregnancy respectively). It has been shown refusal of vitamin D3 is associated with less it’s cord blood level and concentration of anti-inflammatory cytokines than in group II while proinflammatory IL-8 was significantly higher. It has been shown that refusal of vitamin D3 during pregnancy is associated the decrease of cord blood of it and proinflammatory cytokines. At the same time, there were higher dose-dependent increase of concentration of anti-inflammatory IL-4 and IL-10 in group II. The last is the key cytokine associated with immune tolerance requiring for maintenance of pregnancy, but activation of proinflammatory mechanisms may lead to pregnancy interruption.