Key result
Gastrin induces the expression of the prosurvival secretory clusterin in rat adenocarcinoma cells and oxyntic mucosa, which inhibits serum starvation-induced apoptosis.
Population
Rat adenocarcinoma cells, hypergastrinemic rats, normal rat oxyntic mucosa, and human gastric ECL carcinoids
Comparison
Gastrin treatment vs Control (untreated or serum starvation)
Design
Preclinical
Authors
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Preclinical findings only; leaves open whether targeting gastrin-clusterin signaling could modulate apoptosis in human gastric adenocarcinoma.
Gastrin upregulates secretory clusterin, which contributes to its antiapoptotic and growth-promoting effects in gastric mucosa and adenocarcinoma cells.
Fjeldbo et al. (2011) studied Gastric adenocarcinoma / hypergastrinemia. Gastrin was evaluated on Clusterin expression and apoptosis. Gastrin induces the expression of the prosurvival secretory clusterin in rat adenocarcinoma cells and oxyntic mucosa, which inhibits serum starvation-induced apoptosis.
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