Key result
Isoproterenol treatment induced a significantly greater increase in cardiac hypertrophy in 129/SvJ mice (32% increase) compared to C57BL/6J mice (26% increase), revealing strain-dependent adaptations in Ca2+ handling.
Why the study?
Does genetic background influence adaptation to cardiac hypertrophy and Ca2+ handling gene expression in mice subjected to isoproterenol stress?
Population
Male C57BL/6J and 129/SvJ mice (8-13 weeks old)
Comparison
Chronic isoproterenol treatment via… vs Control animals receiving pumps with vehicle only
Design
Preclinical
Follow-up
3 days
Authors
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Strain choice affects mouse hypertrophy model outcomes; leaves open human genetic parallels in Ca2+ adaptation.
Does genetic background influence adaptation to cardiac hypertrophy and Ca2+ handling gene expression in mice subjected to isoproterenol stress?
Effect estimate: 32% increase
Absolute Event Rate: 5.69% vs 4.29%
p-value: p=<0.001
Genetic background significantly influences the physiological and transcriptional response to hypertrophic stress in mice, highlighting the importance of strain selection in cardiovascular models and the potential for personalized medicine.
Waters et al. (2013) studied Cardiac hypertrophy (n=56). Isoproterenol vs. Vehicle control was evaluated on Heart weight/Body weight (Hw/Bw) ratio in 129/SvJ mice (32% increase, p=<0.001). Isoproterenol treatment induced a significantly greater increase in cardiac hypertrophy in 129/SvJ mice (32% increase) compared to C57BL/6J mice (26% increase), revealing strain-dependent adaptations in Ca2+ handling.
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