Key result
A 2-D constrained mixture model of arterial adaptation suggests that biological constraints, such as negligible turnover of elastin, may result in suboptimal adaptations to sustained flow alterations.
A 2-D constrained mixture model demonstrates that biological constraints, such as elastin turnover, can lead to suboptimal arterial adaptations to altered flow.
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No immediate clinical implications for flow-related vascular disease; extends mixture models while leaving open in vivo relevance.
Gleason et al. (2004) studied Arterial growth and remodeling. Sustained alteration in flow was evaluated on Arterial adaptation (geometry, structure, and properties). A 2-D constrained mixture model of arterial adaptation suggests that biological constraints, such as negligible turnover of elastin, may result in suboptimal adaptations to sustained flow alterations.
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