Key result
Severe rheumatic mitral stenosis was associated with significantly lower left atrial reservoir strain compared to controls (14.73% vs 44.11%, p<0.001).
Why the study?
Are left atrial strain parameters measured by two-dimensional speckle tracking echocardiography reduced in patients with severe rheumatic mitral stenosis compared to controls?
Observational (n=120)
Are left atrial strain parameters measured by two-dimensional speckle tracking echocardiography reduced in patients with severe rheumatic mitral stenosis compared to controls?
Absolute Event Rate: 14.73% vs 44.11%
p-value: p=<0.001
Left atrial dysfunction, as measured by speckle tracking echocardiography, is prevalent in patients with severe rheumatic mitral stenosis regardless of NYHA functional class.
Reduced LA reservoir strain signals dysfunction in severe rheumatic mitral stenosis; leaves open its prognostic utility in prospective studies.
We studied left atrial (LA) function in severe rheumatic mitral stenosis (MS) patients using two-dimensional speckle tracking echocardiography (STE). Eighty patients with isolated severe MS in sinus rhythm and 40 controls underwent comprehensive echocardiography including STE derived LA strain [reservoir strain (LASr), conduit strain (LAScd) and contractile strain (LASct)]. The mean MVA was 0.93 ± 0.21 cm2. The mean values of LASr (14.73 ± 8.59%), LAScd (−7.61 ± 4.47%) and LASct (−7.16 ± 5.15%) in patients were significantly lower (p < 0.001) vs. controls 44.11 ± 10.44%, −32.45 ± 7.63%, −11.85 ± 6.77% respectively and showed decreasing trend with increasing MS severity and higher NYHA class. In conclusion, LA dysfunction is prevalent in severe MS irrespective of NYHA functional class.
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Mehta et al. (2021) conducted an observational in Severe rheumatic mitral stenosis (n=120). Severe rheumatic mitral stenosis vs. Controls was evaluated on Left atrial reservoir strain (LASr) (p=<0.001). Severe rheumatic mitral stenosis was associated with significantly lower left atrial reservoir strain compared to controls (14.73% vs 44.11%, p<0.001).
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