Excretion of Bile Acids by Cockerels Fed Different Lipids

THE mechanisms whereby hypo-or hypercholesterolemia is induced by the dietary fats fed in cholesterol-free diets are not completely understood. The effects of fats on blood cholesterol level may be related to differences in the rates of bile acid excretion induced by the fats. Gordon et al. (1957); Byers and Friedman (1958); Haust and Beveridge (1958); Srikantia and Gopalan (1960); Goldsmith et al. (1960); Moore et al. (1962); have all shown that unsaturated fats which reduce blood cholesterol levels also increase excretion of bile acids. On the other hand, Avigan and Steinberg (1965); Lindestedt et al. (1965); Grundy et al. (1965); Ali et al. (1966); found no significant differences in bile acid excretion when fats of different degrees of saturation were fed. The above reports pertained to studies with human subjects, rats or rabbits. Comparatively few studies have been made of bile acid excretion in the chicken despite the considerable use…