A distinct effector B cell population drives autoantibody production in SARS-CoV-2 infection

Dan Yuan; Sarah Li; Rongyu Zhang; Rachel H. Ng; Yapeng Su; Linda Lan; Mahasish Shome; Brett Smith; Pamela Troisch; Jingyi Xie; Jongchan Choi; Rick Edmark; Daniel Chen; Lee Rowen; Amy Nguyen; Rachel Liu; Vanessa Gutierrez; Conor Brennan; Michaela McKasson; Kim Murray; Julie A. Wallick; Heather A. Algren; Alexandria Duven; Brian Piening; Wendy Thomas; Hao Y. Kueh; Andrew T. Magis; Jennifer Hadlock; M Snyder; Jason D. Goldman; James R. Heath

doi:10.1016/j.immuni.2026.08.002

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Abstract

AtMs (double-negative 2, DN2s) in autoAb-high individuals exhibited increased TLR7 signaling, oxidative stress, and isotype switching, regulated by transcription factors T-bet and XBP1. Integrated genetic and genomic analyses showed that DN2s had the strongest enrichment for autoimmune trait heritability and inferred regulatory effects of autoimmune risk variants among B cell subsets. These findings identify DN2s as key precursors of autoAb-producing cells during SARS-CoV-2 infection.

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Yuan et al. (2026) studied this question.

synapsesocial.com/papers/6a96d539f34ac7d5e5823873 https://doi.org/10.1016/j.immuni.2026.08.002

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A distinct effector B cell population drives autoantibody production in SARS-CoV-2 infection

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A distinct effector B cell population drives autoantibody production in SARS-CoV-2 infection

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