Key result
In adult male mice, 14 days of chronic social defeat stress resulted in sustained elevations in blood pressure, increased anxiety-like behavior, and autonomic dysfunction compared with controls.
Why the study?
Social adversity has profound psychological and cardiometabolic consequences, and a better understanding of its cardiometabolic effects was needed.
Does chronic social defeat stress induce cardiometabolic and anxiogenic consequences in adult male mice?
Does chronic social defeat stress induce cardiometabolic and anxiogenic consequences in adult male mice?
Chronic social defeat stress in male mice induces sustained hypertension and autonomic dysfunction, providing a useful model for stress-induced cardiometabolic disease.
Answers are grounded in this paper and cite their sources.
Supports stress-induced hypertension modeling in mice; leaves open human translation and prospective trials.
Social adversity, such as that which occurs during subjugation to a lower social status, has profound psychological and cardiometabolic consequences that are conserved across species. Clinically, such adversity often arises from being of a lower socioeconomic status and may contribute to health disparities in cardiometabolic and affective disorders. To develop a better understanding of the cardiometabolic consequences of social adversity, we employ chronic social defeat stress (CSDS) in adult male mice. CSDS results in increases in body mass, that are accompanied by elevated lean and fluid mass, as well as several somatic indices of chronic stress. Moreover, mice exposed to CSDS exhibit increased anxiety-like behavior, spending more time in the closed arms of the elevated plus maze and less time in the center of an open field arena. Regarding cardiovascular parameters, initial social defeat sessions result in increases in blood pressure, activity, and temperature in comparison with control mice. Interestingly, while blood pressure returns to basal levels by the start of the light cycle for the first few days of defeat, 14 days of CSDS results in sustained elevations in blood pressure, lower activity and lower body temperature. Finally, the results of heart rate variability, spontaneous baroreflex sensitivity and adrenal transcriptome analyses were consistent with CSDS-induced autonomic dysfunction, effects that may contribute to the hypertension observed. Collectively, these data suggest that CSDS may be useful for modeling hypertension induced by chronic social stress, thereby enabling us to better understand the mechanisms that contribute to stress-induced cardiometabolic disease.
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Scott et al. (2025) studied Chronic social defeat stress. Chronic social defeat stress (CSDS) vs. Control mice was evaluated on Cardiometabolic and anxiogenic consequences (blood pressure, body mass, anxiety-like behavior). In adult male mice, 14 days of chronic social defeat stress resulted in sustained elevations in blood pressure, increased anxiety-like behavior, and autonomic dysfunction compared with controls.
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