A metal chelator from the oxygen-free world: Multiple lines of experimental evidence show that closthioamide, the first antibiotic from a strictly anaerobic bacterium (Clostridium), is a selective copper(I) chelator. The geometry of the polythioamide complex, in which two copper ions in a trigonal-planar coordination stabilize the pitch of a helix-like arrangement, is unprecedented for natural products.
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Kloß et al. (2013) studied this question.
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