Highly Efficient Total Synthesis of the Clostridium‐Derived anti‐MRSA Antibiotic Closthioamide

The antibiotic closthioamide from Clostridium cellulolyticum, the first example of a secondary metabolite from strictly anaerobic bacteria, was synthesized by a versatile and highly efficient synthetic route. This starts from simple building blocks and involves convergent peptide coupling and polythionation.