June 25, 2002Proceedings of the National Academy of SciencesOpen Access

Deciphering peripheral nerve myelination by using Schwann cell expression profiling

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Population

C57BL/6 mice and Egr2lo/lo mice with WT littermates.

Comparison

Sciatic nerve crush, transection, and postnatal… vs Uninjured contralateral nerve or wild-type…

Design

Preclinical

Follow-up

up to 28 days post-injury

Authors

RNRakesh NagarajanUniversity of California, San Francisco NLNam LeUniversity of Crete HMHeather MahoneyUniversity Hospital of Wales

Discussion

Member takes

Implication

Does not support clinical use in neuropathies; leaves open MASR as a myelin synthesis target pending validation.

Structured PICO

Population

C57BL/6 mice (at least 10 per time point for nerve crush/transection, 60 P0 and 10 P56 for development) and Egr2lo/lo mice with WT littermates.

Intervention

Sciatic nerve crush, transection, and postnatal development paradigms to induce dynamic changes in myelination status.

Comparator

Uninjured contralateral nerve (for injury models) or wild-type littermates (for Egr2lo/lo mice).

Outcome

Identification of coregulated genes involved in myelination using anchor gene correlation analysis (AGCA) of microarray expression profiles.surrogate

Expression profiling of Schwann cells during dynamic myelination states identified MASR as a crucial enzyme for myelin lipid synthesis, offering insights into peripheral neuropathies.

Cite This Study

Nagarajan et al. (2002) studied this question.

synapsesocial.com/papers/6a96d7482edfdb38688224a4 https://doi.org/10.1073/pnas.132080999

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Deciphering peripheral nerve myelination by using Schwann cell expression profiling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Deciphering peripheral nerve myelination by using Schwann cell expression profiling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider