Key result
Left ventricular apical aneurysm in hypertrophic cardiomyopathy patients aged ≥60 years was associated with an 8-fold higher rate of sudden death compared to those without aneurysms (16% vs 2%; P<0.001).
Why the study?
Does the presence of a left ventricular apical aneurysm increase the risk of sudden death in older patients (≥60 years) with hypertrophic cardiomyopathy?
Cohort
Does the presence of a left ventricular apical aneurysm increase the risk of sudden death in older patients (≥60 years) with hypertrophic cardiomyopathy?
Effect estimate: 8-fold increase
Absolute Event Rate: 16% vs 2%
p-value: p=<0.001
Left ventricular apical aneurysm is a significant risk factor for sudden death in older patients with hypertrophic cardiomyopathy, suggesting that primary prevention with an ICD should be considered even in senior patients.
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Apical aneurysm may mark higher sudden death risk in older HCM patients; leaves open whether it should guide ICD decisions.
Rowin et al. (2018) conducted a cohort in Hypertrophic cardiomyopathy. Left ventricular apical aneurysm vs. No aneurysm was evaluated on Sudden death (8-fold increase, p=<0.001). Left ventricular apical aneurysm in hypertrophic cardiomyopathy patients aged ≥60 years was associated with an 8-fold higher rate of sudden death compared to those without aneurysms (16% vs 2%; P<0.001).