Genetic Correlation of Exercise with Heart Rate and Respiratory Sinus Arrhythmia
Key result
The association between exercise behavior and heart rate or respiratory sinus arrhythmia largely derives from a common genetic factor, contributing 84% and 88% in young and middle-aged twins.
Why the study?
Does a common genetic factor explain the association between exercise behavior and heart rate/respiratory sinus arrhythmia in adolescent and middle-aged twins?
Population
157 adolescent and 208 middle-aged twin pairs, divided into five sex by zygosity groups
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Shared genetics largely explain exercise-HR/RSA links in twins; leaves open whether behavior interventions modify these independently of genotype.
Study Design
Type
Observational (n=730)
Structured PICO
Does a common genetic factor explain the association between exercise behavior and heart rate/respiratory sinus arrhythmia in adolescent and middle-aged twins?
P
Population
730 individuals (365 twin pairs) including adolescents aged 13-22 and middle-aged adults aged 35-62 assessed for exercise behavior and cardiovascular metrics.
E
Exposure
Exercise behavior (average weekly METs spent on sports activities or other vigorous activities in leisure time in the last 3 months)
O
Outcome
Genetic correlation between exercise behavior and respiratory sinus arrhythmia (RSA) and heart period (HP)surrogate
The association between exercise behavior and cardiovascular risk factors such as heart rate and respiratory sinus arrhythmia largely derives from a common genetic factor.
Limitations
- Does not preclude causal effects of exercise on respiratory sinus arrhythmia and heart rate
Cite This Study
Geus et al. (2003) reported an observational. Exercise behavior was evaluated on Genetic correlation between exercise behavior, heart period, and respiratory sinus arrhythmia. The association between exercise behavior and heart rate or respiratory sinus arrhythmia largely derives from a common genetic factor, contributing 84% and 88% in young and middle-aged twins.