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March 23, 2012Journal of Neurophysiology

Baroreflex mechanisms regulating the occurrence of neural spikes in human muscle sympathetic nerve activity

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Population

15 young and healthy individuals (8 males; mean age 24 ± 4 years)

Design

Other

Follow-up

5 minutes

Key result

Arterial baroreflex control strongly regulates the occurrence of small-medium sized action potentials within sympathetic bursts, but has weak control over large action potentials.

Authors

ASAryan SalmanpourJSJ. Kevin Shoemaker

Discussion

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Overview

May indicate size-selective baroreflex regulation of sympathetic outflow; hypothesis-generating for autonomic mechanisms in cardiovascular disease.

Study Design

Type

Observational (n=15)

Structured PICO

P
Population
15 young and healthy individuals (mean age 24 years, 47% female) evaluated during 5 minutes of supine rest to assess baroreflex control of muscle sympathetic nerve activity.
E
Exposure
Measurement of muscle sympathetic nerve activity (MSNA) over 5 minutes of supine rest
O
Outcome
Baroreflex threshold and sensitivity for integrated sympathetic bursts and action potential (AP) clusterssurrogate

Main Result

p-value: p=<0.05

Small-medium sized action potentials within muscle sympathetic nerve activity bursts are governed by baroreflex mechanisms, whereas large action potentials are only weakly associated with baroreflex control.

Cite This Study

Salmanpour et al. (2012) conducted an observational in Healthy (n=15). Arterial baroreflex control was evaluated on Relationship between burst probability and diastolic blood pressure (p=<0.05). Arterial baroreflex control strongly regulates the occurrence of small-medium sized action potentials within sympathetic bursts, but has weak control over large action potentials.

synapsesocial.com/papers/6a96de57f69cd3f692021c25https://doi.org/10.1152/jn.00925.2011
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