Key result
Baroreflex gain calculated from R-R interval responses to arterial pressure ramps triggered by infrequent muscle sympathetic bursts was virtually identical to gain calculated with the noninvasive cross-spectral modulus (mean 24 vs. 24 ms/mmHg, r2=0.91, P<0.001).
Population
11 supine healthy young subjects
Design
Other
Authors
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Noninvasive cross-spectral modulus matches baroreflex gain estimates; supports validation in healthy subjects but leaves open clinical translation.
Observational (n=11)
Yes
Effect estimate: r2 = 0.91
Absolute Event Rate: 24% vs 24%
p-value: p=<0.001
Infrequent human muscle sympathetic bursts are preceded by arterial pressure reductions, reflecting simple baroreflex physiology, and noninvasive low-frequency modulus reliably reproduces baroreflex gains.
Diedrich et al. (2012) conducted an observational in Healthy subjects with infrequent muscle sympathetic bursts (n=11). Isolated muscle sympathetic bursts vs. Cross-spectral modulus (method comparison) was evaluated on Baroreflex gain calculated with linear regression of R-R intervals on systolic pressures after bursts vs. cross-spectral modulus (r2 = 0.91, p=<0.001). Baroreflex gain calculated from R-R interval responses to arterial pressure ramps triggered by infrequent muscle sympathetic bursts was virtually identical to gain calculated with the noninvasive cross-spectral modulus (mean 24 vs. 24 ms/mmHg, r2=0.91, P<0.001).
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