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May 1, 1991Journal of VirologyOpen Access

A domain of the hepadnavirus capsid protein is specifically required for DNA maturation and virus assembly

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Population

Duck hepatitis B virus (DHBV) with mutations introduced into the capsid gene

Design

Preclinical

Authors

MYMei YuNanjing University of Chinese MedicineJSJesse SummersKanazawa University

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Implication

Defines capsid domain essential for hepadnaviral maturation and envelopment; extends mechanistic insights but leaves open human therapeutic translation.

Structured PICO

P
Population
Duck hepatitis B virus (DHBV) with mutations introduced into the capsid gene
I
Intervention
Deletions covering the 3' end of the capsid open reading frame
O
Outcome
Effects on viral DNA synthesis and assembly of enveloped virusessurrogate

A specific domain of the hepadnavirus capsid protein is required for both viral DNA maturation and the assembly of nucleocapsids into envelopes.

Cite This Study

Yu et al. (1991) studied this question.

synapsesocial.com/papers/6a96df4aa43071aed1f6bc8bhttps://doi.org/10.1128/jvi.65.5.2511-2517.1991
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The duck hepatitis B virus core protein contains a highly phosphorylated C terminus that is essential for replication but not for RNA packaging1989 · 84 citations
  2. 2Synthesis of hepadnavirus particles that contain replication-defective duck hepatitis B virus genomes in cultured HuH7 cells1990 · 64 citations
  3. 3A virus in Beechey ground squirrels that is related to hepatitis B virus of humans.1980 · 370 citations
  4. 4Characterization of the major duck hepatitis B virus core particle protein1989 · 96 citations