Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 1, 1994Journal of VirologyOpen Access

Phosphorylation of the duck hepatitis B virus capsid protein associated with conformational changes in the C terminus

View Full Paper
Ask AI
Bookmark
Share

Population

Duck hepatitis B virus (DHBV) capsid protein (262-amino-acid protein)

Design

Preclinical

Authors

MYMing‐Jiun YuNational Taiwan UniversityJSJesse SummersKanazawa University

Discussion

Loading...

Member takes

Implication

Maps DHBV capsid phosphorylation motifs; leaves open in vivo roles in hepadnaviral replication.

Structured PICO

P
Population
Duck hepatitis B virus (DHBV) capsid protein (262-amino-acid protein)
I
Intervention
Site-directed mutagenesis of potential phosphate acceptor sites (serines, threonines, and downstream prolines) in the C terminus
O
Outcome
Phosphorylation status and electrophoretic mobility in sodium dodecyl sulfate gels

Phosphorylation of the DHBV capsid protein requires an SP or TP motif and is associated with specific conformational changes in the C terminus.

Cite This Study

Yu et al. (1994) studied this question.

synapsesocial.com/papers/6a96df7bec20a28d6d823078https://doi.org/10.1128/jvi.68.5.2965-2969.1994
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A domain of the hepadnavirus capsid protein is specifically required for DNA maturation and virus assembly1991 · 84 citations
  2. 2The duck hepatitis B virus core protein contains a highly phosphorylated C terminus that is essential for replication but not for RNA packaging1989 · 84 citations
  3. 3Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification1990 · 327 citations
  4. 4Characterization of the major duck hepatitis B virus core particle protein1989 · 96 citations