Several oral or subcutaneous administrations of 6‐sulfanilamidoindazole (6‐SAI) to adult rats regularly induced acute, self‐limiting arthritis and periarthritis confined primarily to the hind paws. The incidence of arthritis in orally medicated rats was related, in part, to the body weight of the animals at time of the initial feeding. Histologically, the lesions were nonsuppurative and proliferative. Lymphocytes were present in all stages of inflammation preceding the appearance of fibroblasts which were the most consistent and striking cellular components. Inflammation was not associated with anemia, elevation of serum uric acid and blood urea nitrogen concentrations, or alterations in sedimentation rates and total and differential WBC counts. Evidence is presented which suggests that the phlogistic effects of 6‐SAI are independent of crystal formation in the periarticular tissues, provocation of latent mycoplasma infections, kinin formation through activation of the Hageman factor, immediate and delayed type hypersensitivity reactions, and induction of an anaphylactoid‐like reaction.
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Miller et al. (1970) studied this question.
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