Diagnostic study demonstrates improved differentiation of infection stages in schistosomiasis patients, indicating that keyhole limpet haemocyanin antibodies aid clinical diagnosis.
Specific IgG and IgM responses to soluble egg antigen (SEA) and keyhole limpet haemocyanin (KLH) were measured by ELISA in patients with acute and chronic schistosomiasis. The tests based upon IgM and IgG antibodies responses to KLH presented the best diagnostic discrimination, and can be used in conjunction with clinical and epidemiological data to the differential diagnosis of acute schistosomiasis.
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Beck et al. (2004) studied this question.
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