Key result
The In-Person Assessment protocol establishes a multi-day, case-control deep phenotyping methodology to evaluate the relationship between subjective health complaints and objective pathology in 120 former professional American-style football players.
Why the study?
Prior studies of former American-style football players were limited by reliance on subjective self-reported data, inadequate sample sizes, or focus on a single disease process in isolation.
Case-Control (n=120)
Yes
The In-Person Assessment protocol provides a comprehensive multi-modality phenotyping approach to objectively evaluate the interrelatedness of subjective health complaints and objective pathology in former professional American-style football players.
Protocol enables multi-modal phenotyping in retired athletes; leaves open symptom-pathology links for validation.
BACKGROUND: Participation in American-style football (ASF), one of the most popular sports worldwide, has been associated with adverse health outcomes. However, prior clinical studies of former ASF players have been limited by reliance on subjective self-reported data, inadequate sample size, or focus on a single disease process in isolation. OBJECTIVE: To determine the burden of objective multi-system pathology and its relationship with subjective health complaints among former professional ASF players. METHODS: The In-Person Assessment is a case-control, multi-day, deep human phenotyping protocol designed to characterize and quantify pathology among former professional ASF players. Participants, recruited from an on-going large-scale longitudinal cohort study, will include 120 men who report either no health conditions, a single health condition, or multiple health conditions across the key domains of cardiometabolic disease, disordered sleep, chronic pain, and cognitive impairment. Data will be collected from validated questionnaires, structured interviews, physical examinations, multi-modality imaging, and functional assessments over a 3-day study period. A pilot study was conducted to assess feasibility and to obtain participant feedback which was used to shape the final protocol. RESULTS: This study provides a comprehensive assessment of objective multi-system pathology and its relationship with subjective health complaints among former professional ASF players. CONCLUSION: The study will determine whether subjective health complaints among former professional ASF players are explained by objective explanatory pathology and will provide novel opportunities to examine the interrelatedness of co-morbidities. It is anticipated that this protocol will be applicable to other clinical and occupational populations.
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Cortez et al. (2022) conducted a case-control in Health afflictions (cardiometabolic disease, disordered sleep, chronic pain, cognitive impairment) (n=120). Subjective health afflictions (cardiometabolic disease, disordered sleep, chronic pain, cognitive impairment) vs. Unafflicted former players was evaluated on Burden of objective multi-system pathology and its relationship with subjective health complaints. The In-Person Assessment protocol establishes a multi-day, case-control deep phenotyping methodology to evaluate the relationship between subjective health complaints and objective pathology in 120 former professional American-style football players.
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