Key result
Warfarin therapy at the time of admission for a hip fracture was associated with a significantly reduced likelihood of undergoing surgery within 36 hours (OR 0.20), longer hospital stays, and decreased 12-month survival.
Why the study?
Does warfarin therapy at the time of admission increase time to surgery, length of stay, and mortality in patients with a fractured neck of the femur?
Population
1,979 surgically treated patients admitted with a fragility fracture of the femoral neck, median age 85, 29%…
Comparison
Warfarin therapy at the time of admission (n=152) vs Not taking warfarin at the time of admission
Design
Cohort
Follow-up
up to 12 months
Authors
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Warfarin-associated delays and mortality in hip fracture warrant protocol review; leaves open whether reversal improves outcomes.
Cohort (n=1,979)
No
Does warfarin therapy at the time of admission increase time to surgery, length of stay, and mortality in patients with a fractured neck of the femur?
Odds Ratio: 0.2 (95% CI 0.14–0.3)
Absolute Event Rate: 30% vs 71%
p-value: p=<0.0001
Warfarin therapy at the time of admission for hip fracture is associated with significant delays to surgery, longer hospital stays, and decreased 12-month survival.
Lawrence et al. (2016) conducted a cohort in Fractured neck of the femur (hip fracture) (n=1,979). Warfarin therapy vs. Not taking warfarin was evaluated on Surgery within 36 hours (OR 0.20, 95% CI 0.14-0.30, p=<0.0001). Warfarin therapy at the time of admission for a hip fracture was associated with a significantly reduced likelihood of undergoing surgery within 36 hours (OR 0.20), longer hospital stays, and decreased 12-month survival.
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