Key result
Mammalian non-LTR retrotransposons have a complex relationship with their hosts, contributing positively to host genomes while also playing a role in human disease and genetic instability.
This review highlights the dual role of transposable elements in mammalian genomes, contributing to both genetic innovation and human disease.
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Alerts clinicians to retrotransposon contributions in genetic disease; extends evolutionary insights but leaves cardiovascular mechanisms open.
Belancio et al. (2008) reported a review. Mammalian non-LTR retrotransposons was evaluated. Mammalian non-LTR retrotransposons have a complex relationship with their hosts, contributing positively to host genomes while also playing a role in human disease and genetic instability.
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