Key result
Hourly subcutaneous insulin lispro was equally effective and safe as intravenous regular insulin for treating mild and moderate diabetic ketoacidosis in adults, with no mortality or serious side effects.
Why the study?
Does hourly subcutaneous insulin lispro improve time to normalization of metabolic parameters in adult patients with mild and moderate diabetic ketoacidosis compared to intravenous regular insulin?
Population
20 adult patients with mild and moderate diabetic ketoacidosis (DKA)
Comparison
Hourly subcutaneous insulin lispro following an… vs Intravenous regular insulin infusion following…
Design
RCT, Randomly assigned into two groups, Open trial
Authors
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Supports subcutaneous lispro as simpler alternative to IV insulin in mild-moderate DKA; confirms equivalence in this RCT.
RCT (n=20)
Open-label
Randomized
Does hourly subcutaneous insulin lispro improve time to normalization of metabolic parameters in adult patients with mild and moderate diabetic ketoacidosis compared to intravenous regular insulin?
Subcutaneous insulin lispro is as effective and safe as intravenous regular insulin for treating mild to moderate diabetic ketoacidosis in adults.
Ersöz et al. (2006) conducted an RCT in Mild and moderate diabetic ketoacidosis (n=20). Subcutaneous insulin lispro vs. Intravenous regular insulin infusion was evaluated on Time needed for normalisation of serum glucose, beta-hydroxybutyrate, blood pH and urine ketone levels. Hourly subcutaneous insulin lispro was equally effective and safe as intravenous regular insulin for treating mild and moderate diabetic ketoacidosis in adults, with no mortality or serious side effects.
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