Key result
Red blood cells play a key role in the storage, transport, and metabolism of different anti-cancer drugs during their pharmacokinetic distribution to tissues.
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Design
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May inform future dosing strategies in oncology; extends pharmacokinetic models but leaves open clinical validation.
After oral or parenteral administration of chemotherapeutic agents, these drugs are transported to the tissues by the blood in different fractions: plasma water, plasma proteins or cells. In this review, the role of the red blood cell in storage, transport and metabolism of different anti-cancer drugs is described.
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Schrijvers et al. (1999) studied this question. Red blood cells play a key role in the storage, transport, and metabolism of different anti-cancer drugs during their pharmacokinetic distribution to tissues.
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