Fabrication of novel PCL/PGS fibrous scaffold containing HA and GO through simultaneous electrospinning-electrospray technique

Herein, poly(caprolactone)/poly (glycerol sebacate) (PCL/PGS) fibrous structures incorporating hydroxyapatite (HA) and graphene oxide (GO) nanofillers were prepared through two procedures, including electrospinning and simultaneous electrospinning/electrospray procedures. Accordingly, introducing nanofillers into the structures through the simultaneous method led to improving the mechanical strength from 3.69 to 4.95 MPa. The electrospray nanofillers caused improvement of the amorphous regions (up to 83.4%) and increased the degradation rate. Furthermore, the filler-filled electrospun/electrospray sample illustrated the highest cell viability of 94.81 ± 0.5%. The results implied that the simultaneous procedure is promising for fabricating filler-loaded membranes as bone tissue scaffolds.