What question did this study set out to answer?

To evaluate the functional, electrophysiological, and histological outcomes of transferring the contralateral C7 nerve simultaneously to both the axillary and median nerves in a rat model of total brachial plexus avulsion.

January 10, 2020Open Access

Contralateral C7 Transfer to Axillary and Median Nerves in Rats with Total Brachial Plexus Avulsion

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Authors

YLYuzhou LiuSouthwest Medical University FXFeng XiaoNational Agency for New Technologies, Energy and Sustainable Economic Development YZYongqing ZhuangJinan University

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Implication

Controlled animal study demonstrates simultaneous contralateral C7 transfer restores deltoid and flexor function in rats, indicating dual-target reinnervation is feasible.

Key Points

To evaluate the functional, electrophysiological, and histological outcomes of transferring the contralateral C7 nerve simultaneously to both the axillary and median nerves in a rat model of total brachial plexus avulsion.
Allocated 80 Sprague-Dawley rats equally into four groups: cC7 to median nerve (Group A), cC7 to axillary nerve (Group B), cC7 to both median and axillary nerves (Group C), and untreated total brachial plexus avulsion (Group D).
Assessed outcomes through behavioral testing of grip and shoulder abduction, electromyography, muscle fiber cross-sectional area, nerve fiber counts, and muscle atrophy gene expression (MAFbx, MuRF1).
Electromyography positive rates reached 90% (Group A) versus 70% (Group C) in the flexor carpi radialis, and 70% (Group B) versus 60% (Group C) in the deltoid, with no significant differences in functional grip or shoulder abduction between groups.
Flexor carpi radialis cross-sectional area and total median and axillary nerve fiber counts were significantly higher in repaired groups (A, B, and C) compared to unrepaired controls in Group D.
Relative gene expression ratios of muscle degradation markers MAFbx and MuRF1 showed no statistically significant differences among the groups in either the flexor carpi radialis or deltoid muscles.

Cite This Study

Liu et al. (2020) studied this question.

synapsesocial.com/papers/6a96f2bf132cd8a75e57a77a https://doi.org/10.21203/rs.2.20612/v1

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Implication

Controlled animal study demonstrates simultaneous contralateral C7 transfer restores deltoid and flexor function in rats, indicating dual-target reinnervation is feasible.

Contralateral C7 Transfer to Axillary and Median Nerves in Rats with Total Brachial Plexus Avulsion

Discussion

Member takes

Implication

Key Points

Cite This Study

Contralateral C7 Transfer to Axillary and Median Nerves in Rats with Total Brachial Plexus Avulsion

Discussion

Member takes

Implication

Key Points

Cite This Study

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