Key result
A high Neurocognitive Frailty Index score (≥19 deficits) was associated with a significantly increased risk of 5-year mortality compared to a score of ≤4 deficits (HR 9.172).
Why the study?
Hypertension is associated with cognitive decline and frailty, making the prognostic utility of the Neurocognitive Frailty Index important to understand in hypertensive elderly individuals.
Does the Neurocognitive Frailty Index predict cognitive decline and mortality in elderly patients with hypertension?
Cohort (n=997)
Does the Neurocognitive Frailty Index predict cognitive decline and mortality in elderly patients with hypertension?
Hazard Ratio: 9.172 (95% CI 4.122–20.409)
Absolute Event Rate: 57.4% vs 13%
p-value: p=0.001
The Neurocognitive Frailty Index is a significant predictor of 5-year mortality and cognitive decline in the elderly, particularly those with hypertension.
May aid mortality risk stratification in hypertensive elderly; leaves open prospective validation before guiding practice.
According to Statistics Canada in 2014, 23.4% of Canadians aged between 45 and 64-years-old, and 47, 4% of adults aged 65 years and older were diagnosed with hypertension. Given the significant association between Hypertension and cognitive decline, and consequently on frailty status, the contribution of Neurocognitive Frailty Index in the assessment of patient's prognosis is of utmost importance. Hence, the prognostic utility of the Neurocognitive Frailty Index (NFI), a comprehensive measure of frailty in the elderly and a correlated measure of cognitive change, could help shed some light in better understanding of this relationship.
No takes yet. Share an insight, caveat, or question.
Paul et al. (2020) conducted a cohort in Hypertension and cognitive decline in the elderly (n=997). Neurocognitive Frailty Index (NFI) score ≥ 19 deficits vs. NFI score ≤ 4 deficits was evaluated on 5-year mortality (HR 9.172, 95% CI 4.122-20.409, p=0.001). A high Neurocognitive Frailty Index score (≥19 deficits) was associated with a significantly increased risk of 5-year mortality compared to a score of ≤4 deficits (HR 9.172).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: