Key result
Smoking accelerates the progression of diabetic kidney disease through mechanisms involving sustained sympathetic overactivity, atherosclerosis, oxidative stress, and hyperlipidemia.
Why the study?
Diabetic kidney disease is a leading cause of end-stage renal disease and smoking damages renal physiology, prompting a need to elucidate mechanisms underlying the cumulative negative effects of simultaneous hyperglycemia and nicotine exposure.
Does smoking accelerate the progression of diabetic kidney disease in patients with diabetes mellitus?
Does smoking accelerate the progression of diabetic kidney disease in patients with diabetes mellitus?
Smoking exacerbates diabetic kidney disease through multiple pathophysiological pathways, emphasizing the critical need for smoking cessation in diabetic patients.
May inform risk stratification in diabetic kidney disease; extends mechanistic evidence but leaves open randomized cessation trials.
Diabetes is a systemic metabolic disease with serious complications that cause significant stress on the healthcare system. Diabetic kidney disease is the primary cause of end stage renal disease globally and its progression is accelerated by various factors. Another major healthcare hazard is tobacco consumption and smoking has deleterious effects on renal physiology. Prominent factors are defined as sympathetic activity, atherosclerosis, oxidative stress and dyslipidemia. This review aims to enlighten the mechanism underlying the cumulative negative effect of simultaneous exposure to hyperglycemia and nicotine.
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Gündoğdu et al. (2022) conducted a review in Diabetic Nephropathy. Smoking vs. Non-smoking was evaluated. Smoking accelerates the progression of diabetic kidney disease through mechanisms involving sustained sympathetic overactivity, atherosclerosis, oxidative stress, and hyperlipidemia.
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