Key result
Simultaneous activation of the carotid sinus and vagally mediated baroreflex systems resulted in a facilitatory spatial interaction (open-loop gain 6.7 vs sum of separate gains 3.4), with a temporal interaction present when the delay was less than 30 seconds.
Absolute Event Rate: 6.7% vs 3.4%
In a canine model, the carotid sinus and vagally mediated baroreflex systems interact in a facilitatory manner spatially, and exhibit temporal interaction when the vagally mediated baroreflex is activated within 30 seconds of the carotid sinus baroreflex.
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Animal data on baroreflex synergy warrant no practice change; leaves open human translation and therapeutic relevance.
Hosomi et al. (1986) studied Healthy (animal model) (n=25). Simultaneous activation of carotid sinus and vagally mediated baroreflexes vs. Separate activation of the baroreflexes was evaluated on Open-loop gain of the rapidly acting arterial pressure control system. Simultaneous activation of the carotid sinus and vagally mediated baroreflex systems resulted in a facilitatory spatial interaction (open-loop gain 6.7 vs sum of separate gains 3.4), with a temporal interaction present when the delay was less than 30 seconds.
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