Case series demonstrates photocontact dermatitis and extensive chemical cross-sensitivity from antiseptic soaps in patients, highlighting risks of persistent light reactions.
SUMMARY.— Tribromosalicylanilide (T.B.S.) has been used as an antiseptic in soap in Australia since May 1964. Cases of photosensitivity from soap have been recognized since April 1967. Seven cases comprising I persistent light reaction to T.B.S., 5 transient light reactions to T.B.S. and 1 transient light reaction to hexachlorophane are described. All cases were photo‐patch tested to T.B.S., multifungin, fenticlor, bithionol and hexachlorophane, using natural sunlight as the source of ultra‐violet energy. Cross‐sensitivity between all the test chemicals was proven. No differences could be demonstrated between the patch test responses to three grades of T.B.S. used for patch testing, and all cases primarily sensitized to T.B.S. cross‐reacted with multifungin. The nature of the persistent light reaction and the mechanism of its production are discussed.
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Burry et al. (1968) studied this question.
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