Key result
Unloading carotid sinus baroreceptors did not activate hepatic glycogen breakdown or cause a hepatic blood volume response, though hepatic arterial constriction offset blood pressure rises.
Why the study?
Does unloading carotid sinus baroreceptors affect hepatic blood volume, glucose output, and arterial conductance in cats?
Population
Cats (feline model)
Comparison
Unloading carotid sinus baroreceptors using… vs Control state vs hemorrhaged state, and…
Design
Preclinical
Authors
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Does not support baroreflex control of hepatic glycogenolysis or volume in cats; leaves open species-specific mechanisms and human translation.
Does unloading carotid sinus baroreceptors affect hepatic blood volume, glucose output, and arterial conductance in cats?
In a feline model, carotid sinus baroreceptor unloading does not reflexly activate hepatic glycogen breakdown or alter hepatic blood volume, but does cause hepatic arterial constriction.
W. Wayne Lautt (1982) studied this question. Unloading carotid sinus baroreceptors vs. Control and hemorrhaged states was evaluated on Hepatic blood volume, glucose output, and arterial conductance changes. Unloading carotid sinus baroreceptors did not activate hepatic glycogen breakdown or cause a hepatic blood volume response, though hepatic arterial constriction offset blood pressure rises.
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