Key result
Myoblast cultures serve as key mechanistic models for uncovering the cellular and molecular pathways, such as IGF-I and myostatin signaling, that regulate skeletal muscle hypertrophy and atrophy.
Population
Myoblast cultures used as in-vitro models of skeletal muscle hypertrophy and atrophy
Design
Review
Authors
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Myoblast models may advance anti-wasting strategies; leaves open clinical translation pending 3-D validation.
Myoblast models, particularly when advancing to 3-D constructs, are crucial for uncovering the cellular and molecular mechanisms of skeletal muscle hypertrophy and atrophy to develop strategies against muscle wasting.
Sharples et al. (2011) conducted a review in Skeletal muscle hypertrophy and atrophy. Myoblast models was evaluated. Myoblast cultures serve as key mechanistic models for uncovering the cellular and molecular pathways, such as IGF-I and myostatin signaling, that regulate skeletal muscle hypertrophy and atrophy.
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