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January 1, 1999Diseases of the Colon & Rectum

Varying features of early age-of-onset “Sporadic” and hereditary nonpolyposis colorectal cancer patients

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Authors

JGJosé G. GuillemUniversity of North Carolina at Chapel Hill JCJorge Puig–La CalleUniversity of Minnesota CCChristina CelliniUniversity of Rochester Medical Center

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Overview

Cohort study reveals distinct clinicopathologic features and higher metachronous tumor rates in early-onset hereditary nonpolyposis colorectal cancer, suggesting a need for extensive surgical...

Key Points

To identify and compare clinicopathologic characteristics between early-onset hereditary nonpolyposis colorectal cancer and sporadic cases based on detailed family cancer history.
Evaluated 146 early age-of-onset colorectal cancer patients with detailed family history obtained from a registry of 230 consecutive patients over a ten-year period.
Stratified patients into seven categories ranging from fulfillment of strict Amsterdam criteria to no family history of cancer.
Twenty-two of 146 patients (15%) met strict or modified criteria for hereditary nonpolyposis colorectal cancer.
Patients fulfilling hereditary criteria were significantly younger (31 vs. 35 years; P = 0.0003) and had more metachronous colorectal cancers (27% vs. 2%; P = 0.007).
Hereditary nonpolyposis colorectal cancer patients had lower rates of nodal or metastatic spread compared to non-hereditary patients (35% vs. 65%; P = 0.01).

Cite This Study

Guillem et al. (1999) studied this question.

synapsesocial.com/papers/6a96fa4937dc33ab6afbcfdb https://doi.org/10.1007/bf02235180

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January 1, 1999Diseases of the Colon & Rectum

Varying features of early age-of-onset “Sporadic” and hereditary nonpolyposis colorectal cancer patients

View Full Paper

Ask AI

Bookmark

Authors

JGJosé G. GuillemUniversity of North Carolina at Chapel Hill JCJorge Puig–La CalleUniversity of Minnesota CCChristina CelliniUniversity of Rochester Medical Center

Discussion

Member takes

Overview

Cohort study reveals distinct clinicopathologic features and higher metachronous tumor rates in early-onset hereditary nonpolyposis colorectal cancer, suggesting a need for extensive surgical...

Key Points

To identify and compare clinicopathologic characteristics between early-onset hereditary nonpolyposis colorectal cancer and sporadic cases based on detailed family cancer history.
Evaluated 146 early age-of-onset colorectal cancer patients with detailed family history obtained from a registry of 230 consecutive patients over a ten-year period.
Stratified patients into seven categories ranging from fulfillment of strict Amsterdam criteria to no family history of cancer.
Twenty-two of 146 patients (15%) met strict or modified criteria for hereditary nonpolyposis colorectal cancer.
Patients fulfilling hereditary criteria were significantly younger (31 vs. 35 years; P = 0.0003) and had more metachronous colorectal cancers (27% vs. 2%; P = 0.007).
Hereditary nonpolyposis colorectal cancer patients had lower rates of nodal or metastatic spread compared to non-hereditary patients (35% vs. 65%; P = 0.01).

Cite This Study

Guillem et al. (1999) studied this question.

synapsesocial.com/papers/6a96fa4937dc33ab6afbcfdb https://doi.org/10.1007/bf02235180

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