Elevated Serum Free Thyroxine by Thyroxine Analog Radioimmunoassays in Euthyroid Patients with Familial Dysalbuminemic Hyperthyroxinemia

Brief Reports1 December 1982Elevated Serum Free Thyroxine by Thyroxine Analog Radioimmunoassays in Euthyroid Patients with Familial Dysalbuminemic HyperthyroxinemiaRAJATA RAJATANAVIN, M.D., LAWRENCE FOURNIER, A.A., DIANE DeCOSIMO, M.D., CYNTHIA ABREAU, B.S., LEWIS E. BRAVERMAN, M.D.RAJATA RAJATANAVIN, M.D.Search for more papers by this author, LAWRENCE FOURNIER, A.A.Search for more papers by this author, DIANE DeCOSIMO, M.D.Search for more papers by this author, CYNTHIA ABREAU, B.S.Search for more papers by this author, LEWIS E. BRAVERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-6-865 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVarious radioimmunoassay kits have been developed for measuring the serum free thyroxine (T4) concentration. Values for free T4 obtained with these kits correlate well with values obtained by the more cumbersome and time-consuming method of equilibrium dialysis in patients with thyroid dysfunction and abnormalities in the serum thyroxine-binding globulin concentration (1, 2). However, when some of these kits are used to assess serum free T4 in euthyroid patients with nonthyroidal illnesses, the values may be lower than those obtained with equilibrium dialysis (2-5). These discrepancies may limit the clinical usefulness of these methods in ill, euthyroid patients.Familial dysalbuminemic hyperthyroxinemia...References1. BRAVERMANABREAUBROCK LCP. Measurement of serum free thyroxine by RIA in various clinical states. J Nucl Med 1980;21:233-9. MedlineGoogle Scholar2. CHOPRAVAN HERLECHUA TECONGUYEN IAGA. Serum free thyroxine in thyroidal and nonthyroidal illnesses: a comparison of measurements by radioimmunoassay, equilibrium dialysis, and free thyroxine index. J Clin Endocrinol Metab. 1980;51:135-43. CrossrefMedlineGoogle Scholar3. KAPTEINMACINTYREWEINERSPENCERNICOLOFF ESJCJ. Free thyroxine estimates in nonthyroidal illness: comparison of eight methods. J Clin Endocrinol Metab. 1981;52:1073-7. CrossrefMedlineGoogle Scholar4. SLAGMORLEYELSON MJM. Free thyroxine levels in critically ill patients: a comparison of currently available assays. JAMA. 1981;246:2702-6. CrossrefMedlineGoogle Scholar5. MELMEDGEOLAREEDPEKARYPARKHERSHMAN SFAAJJ. A comparison of methods for assessing thyroid function in nonthyroidal illness. J Clin Endocrinol Metab. 1982;54:300-6. CrossrefMedlineGoogle Scholar6. HENNEMANNDOCTERKRENNINGBOSOTTENVISSER GREGMT. Raised total thyroxine and free thyroxine index but normal free thyroxine: a serum abnormality due to inherited increased affinity of iodothyronines for serum binding protein. Lancet. 1979;1:639-42. CrossrefMedlineGoogle Scholar7. LEEGOLDENVAN HERLELIPPEKAPLAN WMABS. Inherited abnormal thyroid hormone-binding protein causing selective increase of total serum thyroxine. J Clin Endocrinol Metab. 1979;49:292-9. CrossrefMedlineGoogle Scholar8. STOCKIGTTOPLISSBARLOWWHITEHURLEYTAFT JDJEDP. Familial euthyroid thyroxine excess: an appropriate response to abnormal thyroxine binding associated with albumin. J Clin Endocrinol Metab. 1981;53:353-9. CrossrefMedlineGoogle Scholar9. RUIZRAJATANAVINYOUNG MRR. Familial dysalbuminemic hyperthyroxinemia: a syndrome that can be confused with thyrotoxicosis. N Engl J Med. 1982;306:635-9. CrossrefMedlineGoogle Scholar10. STOCKIGTDEGARISCSICSMANNBARLOWWHITEHURLEY JMJJED. Limitations of a new free thyroxine assay (Amerlex© Free T4). Clin Endocrinol (Oxf). 1981;15:313-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Massachusetts Medical School Worcester, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA systematic review of genetic studies of thyroid disorders in TaiwanArtifactually Elevated Serum-Free Thyroxine Levels Measured by Equilibrium Dialysis in a Pregnant Woman with Familial Dysalbuminemic HyperthyroxinemiaClinical Aspects and Diagnosis of Thyroid Hormone Transport Protein AnomaliesMeasurement of Thyroid Hormones and Related MoleculesElevated thyroxine levels in a euthyroid patientFamilial dysalbuminaemic hyperthyroxinaemia and inherited partial TBG deficiency: first reportThe Clinical Utility of a Non-Isotopic Two-Step Assay (DELFIA) and an Analogue Radioimmunoassay (SimulTRAC) for Free Thyroxine ComparedThyroid function evaluation by different commercially available free thyroid hormone measurement kits in term pregnant women and their newbornsNon-Isotopic, Two-Step Free Thyroxine Immunoassay: A Better Measure of Free Thyroxine than Analogue RadioimmunoassayTehnical reportsThe evaluation of a chemiluminescent assay for free thyroxine by comparison with equilibrium dialysis in clinical samplesAbnormal Thyroid Function Tests in Euthyroid PatientsStrategies for Cost-Effective Thyroid Function Testing with Modern MethodsThyroid DysfunctionFamilial Dysalbuminemic Hyperthyroxinemia in a Hispanic FamilyJILL M. 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BRAVERMAN, M.D.AN IMMUNOCHEMILUMINOMETRIC ASSAY FOR SERUM FREE THYROXINEA new type of albumin with predominantly increased binding affinity for 3,3′, 5-triiodothyronine in a patient with Graves’ diseaseA four generation study of familial dysalbuminemic hyperthyroxinemia: diagnosis in the presence of an acquired excess of thyroxine-binding globulinFamilial dysalbuminemic hyperthyroxinemia associated with primary thyroid diseaseEuthyroid HyperthyroxinemiaRadioimmunoassay of Thyroid HormonesTHE DIAGNOSTIC CHALLENGE OF EUTHYROID HYPERTHYROXINEMIAControversies in Thyroid Function TestingFamilial dysalbuminemic hyperthyroxinemia (FDH): Inadequacy of the “analog” methods for assaying free-T4 levelsEuthyroid hyperthyroxinemiaLABELLED ANALOGUE "FREE" THYROXINE ASSAYS: THE UNANSWERED QUESTIONSEffect of heparin in vivo on the in vitro assay of free thyroxineNew methods of free T 4 estimation 1 December 1982Volume 97, Issue 6Page: 865-865KeywordsArthritisAttentionEquilibrium dialysisGlobulinsHyperthyroxinemiaRadioimmunoassaysThyroidThyroxine Issue Published: 1 December 1982 PDF DownloadLoading ...