Key result
High doses of vitamin D administered to pregnant rabbits resulted in aortic abnormalities in 41.2% of offspring, compared to 0% in control and vitamin D-deficient offspring.
Why the study?
Does maternal hypervitaminosis D cause congenital supravalvar aortic stenosis in offspring?
Population
Pregnant rabbits and their offspring
Comparison
High doses of vitamin D administered to pregnant… vs Control diet or vitamin D-deficient diet
Design
Preclinical
Follow-up
Up to 3 months of age
Authors
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Maternal hypervitaminosis D may cause supravalvar aortic stenosis-like defects; leaves open human relevance and requires prospective study.
Does maternal hypervitaminosis D cause congenital supravalvar aortic stenosis in offspring?
Absolute Event Rate: 41.2% vs 0%
Maternal hypervitaminosis D in a rabbit model leads to transplacental passage and causes aortic abnormalities in offspring that anatomically resemble human supravalvar aortic stenosis.
Friedman et al. (1966) studied Supravalvar aortic stenosis syndrome (n=78). High doses of vitamin D vs. Control diet and vitamin D-deficient diet was evaluated on Abnormalities of the aorta. High doses of vitamin D administered to pregnant rabbits resulted in aortic abnormalities in 41.2% of offspring, compared to 0% in control and vitamin D-deficient offspring.
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