Key result
The ACE DD genotype was more prevalent among women with recurrent miscarriages (p=0.02) and associated with the highest number of miscarriages (p=0.03) but similar complete fertility.
Why the study?
Is the ACE I/D polymorphism associated with recurrent miscarriages and reproductive success in women with pre-modern reproductive behavior?
Population
88 Italian women born before 1930, with a pre-modern reproductive behaviour
Comparison
ACE I/D polymorphism (DD genotype) vs Other ACE genotypes
Design
Cross-sectional
Authors
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ACE DD genotype was associated with recurrent miscarriages; hypothesis-generating and should not yet change clinical practice.
Observational (n=88)
Is the ACE I/D polymorphism associated with recurrent miscarriages and reproductive success in women with pre-modern reproductive behavior?
p-value: p=0.02
The ACE DD genotype is associated with recurrent miscarriages but did not reduce overall reproductive success in a historical cohort with pre-modern reproductive behaviors.
Corbo et al. (2010) conducted an observational in Recurrent spontaneous miscarriages (n=88). ACE DD genotype vs. Other ACE genotypes was evaluated on Recurrent spontaneous miscarriages (p=0.02). The ACE DD genotype was more prevalent among women with recurrent miscarriages (p=0.02) and associated with the highest number of miscarriages (p=0.03) but similar complete fertility.
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