Key result
ACE I/D and MTHFR C677T gene polymorphisms showed no statistically significant association with recurrent pregnancy loss in South Indian women.
Why the study?
Are ACE and MTHFR gene polymorphisms associated with unexplained recurrent pregnancy loss in South Indian women?
Population
224 South Indian women, comprising 104 with unexplained Recurrent Pregnancy Loss (RPL) and 120 controls.
Comparison
Genotyping of ACE Insertion Deletion and MTHFR… vs Controls (women without RPL)
Design
Case-control
Authors
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No support for testing these polymorphisms in South Indian women with recurrent pregnancy loss; leaves role in other populations open for replication.
Case-Control (n=224)
Are ACE and MTHFR gene polymorphisms associated with unexplained recurrent pregnancy loss in South Indian women?
ACE I/D and MTHFR C677T polymorphisms are not associated with unexplained recurrent pregnancy loss in South Indian women.
Venkatesan et al. (2008) conducted a case-control in Recurrent Pregnancy Loss (n=224). ACE I/D and MTHFR C677T polymorphisms vs. Control group (women without recurrent pregnancy loss) was evaluated on Distribution of genotypes between cases and controls. ACE I/D and MTHFR C677T gene polymorphisms showed no statistically significant association with recurrent pregnancy loss in South Indian women.
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