Key result
The ACE I/D polymorphism was significantly associated with recurrent pregnancy loss risk under the allele model (I vs D: OR 0.538; 95% CI 0.451-0.643; p≤0.001).
Why the study?
Is the ACE I/D polymorphism associated with an increased risk of recurrent pregnancy loss?
Population
26 case-control studies pooling 3,140 cases of recurrent pregnancy loss (RPL) and 3,370 controls
Comparison
Angiotensin-converting enzyme gene… vs Controls without recurrent pregnancy loss
Design
Meta-analysis
Authors
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May inform risk stratification in recurrent pregnancy loss; leaves open clinical utility and causality pending prospective trials.
Meta-Analysis (n=6,510)
Is the ACE I/D polymorphism associated with an increased risk of recurrent pregnancy loss?
Odds Ratio: 0.538 (95% CI 0.451–0.643)
p-value: p=≤ 0.001
The ACE I/D polymorphism is associated with an increased risk of recurrent pregnancy loss, particularly in Caucasian and West-Asian populations.
Aslbahar et al. (2018) conducted a meta-analysis in recurrent pregnancy loss (n=6,510). ACE I/D polymorphism (I allele) vs. D allele was evaluated on recurrent pregnancy loss risk (OR 0.538, 95% CI 0.451-0.643, p=≤ 0.001). The ACE I/D polymorphism was significantly associated with recurrent pregnancy loss risk under the allele model (I vs D: OR 0.538; 95% CI 0.451-0.643; p≤0.001).
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