Key result
Women carrying the DD or ID genotypes of the ACE I/D polymorphism had a 72% elevated risk of developing idiopathic recurrent pregnancy loss compared to those with the II genotype.
Why the study?
Does the ACE I/D polymorphism increase the risk of idiopathic recurrent pregnancy loss in women?
Population
1176 women from Sanliurfa province, Turkey, including 1007 cases with a history of ≥ 2 consecutive pregnancy…
Comparison
Presence of ACE I/D polymorphism vs Presence of ACE II genotype
Design
Case-control
Authors
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Should not yet change clinical practice; hypothesis-generating for ACE I/D in idiopathic recurrent pregnancy loss.
Case-Control (n=1,176)
No
Does the ACE I/D polymorphism increase the risk of idiopathic recurrent pregnancy loss in women?
Odds Ratio: 1.72 (95% CI 1.181–2.5)
p-value: p=0.00433
The ACE I/D polymorphism (DD or ID genotypes) is significantly associated with an increased risk of idiopathic recurrent pregnancy loss in a Turkish population.
Evren Gümüş (2018) conducted a case-control in Idiopathic recurrent pregnancy loss (n=1,176). ACE I/D polymorphism (DD or ID genotypes) vs. ACE II genotype was evaluated on Idiopathic recurrent pregnancy loss (OR 1.72, 95% CI 1.181-2.500, p=0.00433). Women carrying the DD or ID genotypes of the ACE I/D polymorphism had a 72% elevated risk of developing idiopathic recurrent pregnancy loss compared to those with the II genotype.