Key result
The ACE I/D gene polymorphism allele D was associated with an increased risk of pre-eclampsia compared with allele I (OR 1.29; 95% CI 1.12-1.50; P<0.05).
Why the study?
Studies evaluating the relationship between angiotensin-converting enzyme insertion/deletion polymorphism and pre-eclampsia susceptibility have yielded inconclusive conclusions.
Is the ACE I/D gene polymorphism associated with an increased risk of pre-eclampsia in pregnant women?
Comparison
ACE I/D gene polymorphisms (e.g. allele D vs allele I)
Design
Meta-analysis
Authors
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May guide risk models in select populations; confirms association but leaves clinical utility open.
Meta-Analysis (n=7,096)
Is the ACE I/D gene polymorphism associated with an increased risk of pre-eclampsia in pregnant women?
Odds Ratio: 1.29 (95% CI 1.12–1.5)
p-value: p=< 0.05
The ACE I/D gene polymorphism, specifically allele D and genotype DD, is associated with an increased risk of pre-eclampsia in pregnant women, particularly in Caucasians.
Liu et al. (2020) conducted a meta-analysis in Pre-eclampsia (n=7,096). ACE I/D gene polymorphism (Allele D) vs. Allele I was evaluated on Pre-eclampsia susceptibility (OR 1.29, 95% CI 1.12-1.50, p=< 0.05). The ACE I/D gene polymorphism allele D was associated with an increased risk of pre-eclampsia compared with allele I (OR 1.29; 95% CI 1.12-1.50; P<0.05).
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