Key result
ACE I/D and AT1R gene polymorphisms were not associated with preeclampsia, though ACE DD and ID genotypes were linked to severe proteinuria and renal dysfunction in affected patients.
Why the study?
Are ACE I/D and AT1R gene polymorphisms associated with preeclampsia and renal dysfunction in Chinese women?
Population
238 Chinese women, comprising 133 patients with preeclampsia and 105 healthy pregnant women
Comparison
ACE I/D and AT1R A1166C gene polymorphisms vs Healthy pregnant women and comparison between…
Design
Case-control
Authors
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No role for these polymorphisms in preeclampsia risk stratification; hypothesis-generating for ACE variants in renal dysfunction among affected patients.
Case-Control (n=238)
Are ACE I/D and AT1R gene polymorphisms associated with preeclampsia and renal dysfunction in Chinese women?
While ACE and AT1R gene polymorphisms are not associated with the development of preeclampsia, the ACE D allele may increase susceptibility to renal dysfunction in affected patients.
Li et al. (2007) conducted a case-control in Preeclampsia (n=238). ACE I/D and AT1R gene polymorphisms vs. Healthy pregnant women was evaluated on Frequency of genotypes of the ACE gene and the AT1R gene in preeclampsia vs normal pregnancy. ACE I/D and AT1R gene polymorphisms were not associated with preeclampsia, though ACE DD and ID genotypes were linked to severe proteinuria and renal dysfunction in affected patients.
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