Why the study?
Are ACE I/D and AT1R A1166C gene polymorphisms associated with an increased risk of preeclampsia in pregnant women?
Are ACE I/D and AT1R A1166C gene polymorphisms associated with an increased risk of preeclampsia in pregnant women?
The ACE I/D polymorphism, specifically the D allele, is associated with an increased risk of preeclampsia in pregnant women in South East Iran.
ACE D allele was associated with preeclampsia risk in this case-control study; hypothesis-generating and should not yet change practice or screening.
Some evidence suggests that a variety of genetic factors contributed in pathogenesis of the preeclampsia. The aim of this study was to assess the association between the angiotensin-converting enzyme (ACE) I/D and angiotensin II type1 receptor A1166C polymorphisms with preeclampsia. This study was performed in 125 preeclamptic pregnant women and 132 controls. The I/D Polymorphism of the ACE gene was assessed by polymerase chain reaction and the A1166C Polymorphism of the AT1R gene was determined by restriction fragment length polymorphism. The genotype and allele frequencies of I/D polymorphism differed between two groups. The risk of preeclampsia was 3.2-fold in pregnant women with D allele (OR, 3.2 [95% CI, 1.1 to 3.8]; P = 0.01). The distribution of the AT1R gene A1166C polymorphism was similar in affected and control groups. Our results supported that presence of the I/D polymorphism of ACE gene is a marker for the increased risk of preeclampsia.
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Salimi et al. (2011) studied this question.
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