Why the study?
Is the ACE I/D gene polymorphism associated with changes in plasma ACE, renin activity, and endothelial function in preeclamptic patients?
Is the ACE I/D gene polymorphism associated with changes in plasma ACE, renin activity, and endothelial function in preeclamptic patients?
The ACE DD genotype is associated with altered renin-angiotensin-aldosterone system activity and impaired endothelial function in patients with preeclampsia.
Hypothesis-generating for ACE I/D genotyping in preeclampsia; prospective studies needed before any clinical application.
The association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism with plasma ACE, renin activity and endothelial function of skin microvassals were studied. Preeclamptic patients with the DD genotype of ACE I/D gene polymorphism have lowest plasma renin activity level and endothelium-dependent vasodilatation, D allele carriers have highest plasma ACE activity.
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Radkov et al. (2011) studied this question.
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