Why the study?
Does the ACE insertion/deletion (I/D) polymorphism influence the risk of diabetic nephropathy and response to ACE inhibitors or ARBs?
Does the ACE insertion/deletion (I/D) polymorphism influence the risk of diabetic nephropathy and response to ACE inhibitors or ARBs?
The ACE I/D polymorphism, particularly the DD genotype, is associated with higher ACE levels and may influence the risk of diabetic nephropathy and response to RAS blockade.
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Associates DD genotype with elevated ACE levels; leaves open its role in diabetic nephropathy risk or RAS inhibitor response.
Zohreh Rahimi (2012) studied this question.
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