Key result
The DD polymorphism of the angiotensin converting enzyme gene was associated with the presence of nephropathy in patients with type II diabetes.
Why the study?
Is the ACE DD gene polymorphism associated with nephropathy in patients with type II diabetes?
Case-Control (n=60)
Is the ACE DD gene polymorphism associated with nephropathy in patients with type II diabetes?
The ACE DD gene polymorphism appears to be associated with the development of nephropathy in patients with type II diabetes.
Does not warrant routine ACE genotyping in type 2 diabetes; hypothesis-generating association needs prospective validation.
Nephropathy is an important and a frequent complication of long-term type II diabetic nephropathy. Strong evidence exists that genetic predisposition plays a major role in the development of diabetic nephropathy. Recent studies have implicated association between angiotensin converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and nephropathy. The deletion gene polymorphism of ACE gene has been shown to be associated with increased activity of this enzyme. This study examines the association of ACE I/D polymorphism with type II diabetes without nephropathy in 30 patients and type II diabetes with nephropathy in 30 patients. The results of the study suggest the association between the DD polymorphism and type II diabetes with nephropathy.
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Kumar et al. (2009) conducted a case-control in Type II diabetes with and without nephropathy (n=60). ACE I/D gene polymorphism (DD genotype) vs. Other ACE genotypes / Type II diabetes without nephropathy was evaluated on Diabetic nephropathy. The DD polymorphism of the angiotensin converting enzyme gene was associated with the presence of nephropathy in patients with type II diabetes.
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