Key result
The ACE gene II genotype was significantly more prevalent in T2DM patients without DPN compared to the DD genotype (P<0.05), suggesting a protective effect against DPN development.
Why the study?
Does the ACE gene II genotype protect against the development of diabetic peripheral neuropathy in patients with type 2 diabetes mellitus?
Case-Control (n=1,103)
Does the ACE gene II genotype protect against the development of diabetic peripheral neuropathy in patients with type 2 diabetes mellitus?
Answers are grounded in this paper and cite their sources.
The ACE gene II genotype is associated with a protective effect against the development of diabetic peripheral neuropathy in patients with type 2 diabetes mellitus.
BACKGROUND: Diabetic peripheral neuropathy (DPN) is one of the complications of type 2 diabetes mellitus (T2DM) that decreases the quality of life of T2DM patients. Very few studies have found an association between the development and progression of DPN in T2DM and angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphisms. METHODS: Using gene-specific primers in a polymerase chain reaction, the presence of ACE I/D polymorphisms was screened for in 276 T2DM patients with DPN, 496 T2DM patients without DPN, and 331 control (non-diabetic) subjects. RESULTS: The distribution of the I/D genotypes was in Hardy-Weinberg equilibrium. The II genotype was significantly more prevalent in T2DM patients without DPN than the DD genotype (P < 0.05); however, there was no significant difference in the prevalence of the II and DD genotypes in T2DM patients with DPN (P = 0.78). CONCLUSION: The II genotype of the ACE gene has a protective effect against the development of DPN in T2DM patients. This suggests a role for the renin-angiotensin system in modulating neuropathy in T2DM.
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Mansoor et al. (2012) conducted a case-control in Type 2 diabetes mellitus with and without diabetic peripheral neuropathy (n=1,103). ACE gene II genotype vs. ACE gene DD genotype was evaluated on Prevalence of ACE I/D genotypes in T2DM patients with and without DPN (p=<0.05). The ACE gene II genotype was significantly more prevalent in T2DM patients without DPN compared to the DD genotype (P<0.05), suggesting a protective effect against DPN development.
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