Key result
The ID and DD polymorphisms of the ACE gene increased the odds of developing diabetic nephropathy by 4.8 and 2.9 times, respectively, in Filipino type 2 diabetic patients.
Why the study?
Is the ACE gene I/D polymorphism associated with an increased risk of diabetic nephropathy in Filipino type 2 diabetes patients?
Population
66 Filipinos, comprising 42 type 2 diabetic patients (21 with nephropathy, 21 without) and 24 normal controls.
Comparison
Angiotensin I-converting enzyme gene… vs II genotype
Design
Case-control
Authors
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ACE I/D variants may raise nephropathy risk in Filipino T2D patients; hypothesis-generating and requires prospective validation before clinical use.
Case-Control (n=66)
Is the ACE gene I/D polymorphism associated with an increased risk of diabetic nephropathy in Filipino type 2 diabetes patients?
Odds Ratio: 4.8
The D allele of the ACE gene may be associated with increased susceptibility to diabetic nephropathy in Filipino patients with type 2 diabetes.
Paz-Pacheco et al. (2012) conducted a case-control in Type 2 Diabetes Mellitus and Diabetic Nephropathy (n=66). ACE gene ID or DD polymorphism vs. ACE gene II polymorphism was evaluated on Development of diabetic nephropathy (OR 4.8). The ID and DD polymorphisms of the ACE gene increased the odds of developing diabetic nephropathy by 4.8 and 2.9 times, respectively, in Filipino type 2 diabetic patients.
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