Key result
The I/D polymorphism of the ACE gene was not associated with diabetic nephropathy in Korean IDDM patients (p=0.78 for genotype distribution).
Why the study?
Is the ACE gene I/D polymorphism associated with diabetic nephropathy in Korean IDDM patients?
Population
166 Korean subjects, comprising 59 Insulin-Dependent Diabetes Mellitus patients and 107 control subjects.
Comparison
Angiotensin I converting enzyme gene… vs Control subjects and IDDM patients without…
Design
Case-control
Authors
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No association in this Korean cohort cautions against broad genetic screening; leaves open ethnic differences versus Caucasian reports.
Case-Control (n=166)
Is the ACE gene I/D polymorphism associated with diabetic nephropathy in Korean IDDM patients?
p-value: p=0.78
The I/D polymorphism of the ACE gene is not associated with diabetic nephropathy in Korean IDDM patients, highlighting potential ethnic differences in genetic predisposition compared to Caucasian populations.
Oh et al. (1996) conducted a case-control in Insulin-Dependent Diabetes Mellitus (IDDM) and diabetic nephropathy (n=166). ACE gene I/D polymorphism vs. Absence of diabetic nephropathy / Control subjects was evaluated on ACE genotype distributions in diabetic subjects with or without nephropathy (p=0.78). The I/D polymorphism of the ACE gene was not associated with diabetic nephropathy in Korean IDDM patients (p=0.78 for genotype distribution).
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