Key result
ACE gene insertion/deletion polymorphism was not significantly associated with coronary artery disease in Koreans, although the overall I allele frequency (0.58) differed from other populations.
Why the study?
Is the insertion/deletion polymorphism of the ACE gene associated with coronary artery disease in the Korean population?
Case-Control (n=291)
Is the insertion/deletion polymorphism of the ACE gene associated with coronary artery disease in the Korean population?
The ACE gene I/D polymorphism is unlikely to be a useful marker for coronary artery disease in the Korean population, despite ethnic differences in allele frequencies.
Answers are grounded in this paper and cite their sources.
Does not support ACE I/D testing for CAD risk stratification in Koreans; leaves open whether ethnic allele frequency differences modify associations elsewhere.
In view of the clinical importance of angiotensin-converting enzyme (ACE) as a major marker for cardiovascular diseases, we investigated insertion/deletion (I/D) polymorphism of the ACE gene in Koreans. Genotype frequencies were examined by polymerase chain reaction in 171 patients with coronary artery disease (CAD) and 120 healthy subjects. Allele frequencies of ACE polymorphism in Koreans were not significantly different between patient and control groups. In addition, association between ACE genotypes and the number of stenosed coronary arteries was not detected. ACE genotypes in the CAD group were not associated with body mass index and plasma lipid levels. Thus, our results suggest that, at least in Koreans, I/D polymorphism of the gene is unlikely to be a useful marker for CAD subjects. However, the I allele frequency of Koreans (0.58) was higher than that of Caucasian populations (0.47) but lower than that of Samoan (0.91) and Yanomami (0.85) populations. Here, we discuss the clinical and ethnic importance of ACE polymorphism.
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Hong et al. (1997) conducted a case-control in Coronary artery disease (n=291). ACE gene insertion/deletion (I/D) polymorphism vs. Healthy subjects was evaluated on Allele frequencies of ACE polymorphism. ACE gene insertion/deletion polymorphism was not significantly associated with coronary artery disease in Koreans, although the overall I allele frequency (0.58) differed from other populations.
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